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Promethazine
Clinical data
Trade namesMany [1]
AHFS/Drugs.comMonograph
MedlinePlusa682284
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationOral, rectal, IV, IM, topical
ATC codeD04AA10 ( WHO ) R06AD02 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral
Pharmacokinetic data
Bioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2]
Protein binding93%
MetabolismHepatic glucuronidation and sulfoxidation
Elimination half-life16–19 hours [2] [3]
ExcretionRenal and biliary

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You also need to understand what is going to happen in the future in order to know where to work, live and invest. Our task is to provide you with the best quality medicines for people suffering from Unwanted Pregnancy,cough,cancer, Pains,Erectile Dysfunctions, Sleeping disorders, Obesity and others willing to please them selves.

Discovery and development of memantine and related compounds Memantine was first synthesized and patented by Eli Lilly and Company in as an anti-diabetic agent, but it was ineffective at lowering blood sugar. It can be noted that memantine is an antagonist at Alpha-7 nAChRwhich may contribute to initial worsening of cognitive function during early memantine treatment.

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Comment №1 about product

The low affinity, uncompetitive nature, and rapid off-rate kinetics of memantine at the level of the NMDA receptor-channel, however, preserves the function of the receptor at synapses, as it can still be activated by physiological release of glutamate following depolarization of the postsynaptic neuron.


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Targeting the glutamatergic system, specifically NMDA receptors , offers a novel approach to treatment in view of the limited efficacy of existing drugs targeting the cholinergic system.


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Comment №4 about product

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